Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9208101 | 0.82 | KDM4E (0.49) | KDM4ESMN1; SMN2KMT2ATSHRALDH1A1 | |
| SCHEMBL9371797 | 0.80 | KDM4E (0.40) | KDM4EKMT2AALDH1A1POLB | |
| SCHEMBL1126831 | 0.77 | KDM4E (0.46) | KDM4ESMN1; SMN2GAACYP1A2CYP2C19 | |
| SCHEMBL21233125 | 0.76 | CA12 (0.42) | KDM4ESMN1; SMN2GAAKMT2ATSHR | |
| SCHEMBL9735633 | 0.75 | AKR1B1 (0.48) | KDM4EKMT2ATSHRALDH1A1LMNA | |
| SCHEMBL11233575 | 0.74 | CA2 (0.46) | KDM4ECYP2C19KMT2ATSHRALDH1A1 | |
| SCHEMBL9224894 | 0.72 | CRHBP (0.43) | KDM4ECYP2C19KMT2AALDH1A1LMNA | |
| SCHEMBL1126792 | 0.72 | RAB9A (0.47) | KDM4ESMN1; SMN2GAAKMT2AL3MBTL1 | |
| SCHEMBL22951294 | 0.72 | CA12 (0.40) | KDM4ESMN1; SMN2GAAKMT2AL3MBTL1 | |
| SCHEMBL1126796 | 0.70 | CNR2 (0.46) | KDM4ESMN1; SMN2GAACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0282365-B1 | 1-DETHIA-2-THIA-CEPHALOSPORANIC-ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS THERAPEUTIC AGENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-05-12 | — | — | EP | disclosed |
| US-4908359-A | Pharmaceuticals | Uclaf, Roussel (FR) | 1990-03-13 | — | — | US | disclosed |
| EP-0282365-A1 | 1-Dethia-2-thia-cephalosporanic-acid derivatives, process for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them | ROUSSEL-UCLAF (FR) | 1988-09-14 | — | — | EP | disclosed |