Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 2/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.38 |
| ▸ | ITGAL | P20701 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522481 | 0.89 | FOLH1 (0.41) | FOLH1ALOX15ALBITGB2ICAM1 | |
| SCHEMBL9306542 | 0.83 | FOLH1 (0.36) | TNFFOLH1ALOX15KDM4EPTGS2 | |
| SCHEMBL16023701 | 0.76 | TNF (0.47) | TNFFOLH1LMNAALOX15KDM4E | |
| SCHEMBL468855 | 0.75 | FOLH1 (0.70) | TNFFOLH1LMNATHRBITGB3 | |
| SCHEMBL468853 | 0.75 | FOLH1 (0.70) | TNFFOLH1LMNATHRBITGB3 | |
| SCHEMBL5319562 | 0.73 | LMNA (0.54) | LMNAALOX15KDM4EMAPTTHRB | |
| SCHEMBL468823 | 0.73 | MME (0.60) | FOLH1LMNAALOX15KDM4EMAPT | |
| SCHEMBL9787629 | 0.73 | MME (0.60) | FOLH1LMNAALOX15KDM4EMAPT | |
| SCHEMBL328475 | 0.73 | MME (0.60) | FOLH1LMNAALOX15KDM4EMAPT | |
| SCHEMBL29367167 | 0.73 | MME (0.60) | FOLH1LMNAALOX15KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5273885-A | Using a polyiodothyronine analog of a phenyl compound containing a hydroxyl group ortho to an iodine | SYNTEX (U.S.A.) INC. (US) | 1993-12-28 | — | — | US | disclosed |