Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.37 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523480 | 0.94 | MAPT (0.34) | RIPK1MAPTTP53CCNA2CDK2 | |
| SCHEMBL9831040 | 0.93 | RIPK1 (0.41) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9523934 | 0.91 | IKBKB (0.37) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9316263 | 0.90 | RIPK1 (0.41) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9833865 | 0.90 | POLB (0.39) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9522374 | 0.90 | RIPK1 (0.39) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9316496 | 0.90 | MEN1 (0.40) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL10571543 | 0.89 | RIPK1 (0.42) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9523690 | 0.88 | RIPK1 (0.38) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9522378 | 0.88 | RIPK1 (0.38) | RIPK1KCNJ6KCNJ3KCNJ5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5166152-A | Immunostimulants, bactericides, viricides, antitumor agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-24 | — | — | US | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |