Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19002290 | 0.91 | MTNR1A (0.51) | MTNR1AMTNR1BPPARD | |
| SCHEMBL1844672 | 0.88 | SIRT1 (0.53) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 | |
| SCHEMBL31613070 | 0.87 | HSD17B10 (0.49) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 | |
| Hydrochloric Acid SCHEMBL10467836 | 0.87 | SIRT1 (0.52) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 | |
| SCHEMBL30940169 | 0.87 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 | |
| SCHEMBL10467833 | 0.87 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 | |
| SCHEMBL14711226 | 0.87 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 | |
| SCHEMBL9740277 | 0.85 | TAS1R3 (0.49) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 | |
| SCHEMBL9523174 | 0.85 | TAS1R3 (0.49) | TAS1R3TAS1R1TAS1R2KDM4CMTNR1B | |
| SCHEMBL9522314 | 0.82 | C5AR1 (0.46) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0325963-B1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES AND -INDANES | ABBOTT LABORATORIES (US) | 1993-09-22 | — | — | EP | disclosed |
| US-5140040-A | Alpha-2-adrenergic receptor antagonist; glaucoma; congestive heart failure; hypotensive agents; headaches; metabolic disorders (diabetes, obesity) | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-5128362-A | Antidepressant, antiglaucoma | ABBOTT LABORATORIES (US) | 1992-07-07 | — | — | US | disclosed |
| US-5086074-A | Selective adrenergic receptor antagonists | ABBOTT LABORATORIES (US) | 1992-02-04 | — | — | US | disclosed |
| EP-0395734-A4 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | — | 1991-01-02 | — | — | EP | disclosed |
| EP-0395734-A1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | ABBOTT LABORATORIES (US) | 1990-11-07 | — | — | EP | disclosed |
| EP-0325963-A1 | 1-Aminomethyl-1,2,3,4-tetrahydronaphthalenes and -indanes | ABBOTT LABORATORIES (US) | 1989-08-02 | — | — | EP | disclosed |
| WO-1989006645-A1 | 1-AMINOMETHYL-1,2,3,4-TETRAHYDRONAPHTHALENES | ABBOTT LABORATORIES (US) | 1989-07-27 | — | — | WO | disclosed |