Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.43 |
| ▸ | NQO2 | P16083 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31613077 | 0.89 | MTNR1A (0.52) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL14711226 | 0.86 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2KDM4CMEN1 | |
| SCHEMBL30940169 | 0.86 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2KDM4CMEN1 | |
| SCHEMBL31613068 | 0.85 | KDM4C (0.48) | KDM4CMTNR1AMTNR1B | |
| SCHEMBL9523155 | 0.85 | TAS1R3 (0.49) | TAS1R3TAS1R1TAS1R2KDM4CMEN1 | |
| SCHEMBL1844672 | 0.85 | SIRT1 (0.53) | TAS1R3TAS1R1TAS1R2KDM4CMEN1 | |
| SCHEMBL10467833 | 0.83 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2KDM4CMEN1 | |
| Hydrochloric Acid SCHEMBL10467836 | 0.83 | SIRT1 (0.52) | TAS1R3TAS1R1TAS1R2KDM4CCHRNA7 | |
| SCHEMBL31613070 | 0.83 | HSD17B10 (0.49) | TAS1R3TAS1R1TAS1R2KDM4CMEN1 | |
| SCHEMBL9523174 | 0.81 | TAS1R3 (0.49) | TAS1R3TAS1R1TAS1R2KDM4CMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5140040-A | Alpha-2-adrenergic receptor antagonist; glaucoma; congestive heart failure; hypotensive agents; headaches; metabolic disorders (diabetes, obesity) | ABBOTT LABORATORIES (US) | 1992-08-18 | — | — | US | disclosed |
| US-4957914-A | ANTIDEPRESSANTS, ANXIOLYTICS, HYPOTENSIVE AGENTS | SYNTEX (U.S.A.) INC. (US) | 1990-09-18 | — | — | US | disclosed |