SCHEMBL9523548

SCHEMBL9523548

COCc1cc(CCCOc2ccc(-c3noc(C)n3)cc2C(F)(F)F)on1

nearest known ligand 0.45

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
S1PR1 P21453 17/20 0.45
NR1I2 O75469 1/20 0.42
CYP3A4 P08684 1/20 0.42
CYP2D6 P10635 1/20 0.42
SPHK2 Q9NRA0 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9521541 0.82 AOC3 (0.43) S1PR1NR1I2CYP3A4CYP2D6
SCHEMBL9520640 0.81 MAPT (0.40) S1PR1CYP3A4CYP2D6
SCHEMBL9521081 0.81 MAPT (0.41) S1PR1
SCHEMBL8137702 0.79 NR1I2 (0.68) S1PR1NR1I2CYP3A4CYP2D6
SCHEMBL9521718 0.78 CYP3A4 (0.55) S1PR1NR1I2CYP3A4CYP2D6
SCHEMBL9521646 0.77 S1PR1 (0.50) S1PR1
SCHEMBL9520566 0.76 NR1I2 (0.44) NR1I2CYP3A4CYP2D6SPHK2
SCHEMBL9522218 0.76 MAPT (0.39)
SCHEMBL9521817 0.74 CYP3A4 (0.51) S1PR1NR1I2CYP3A4CYP2D6
SCHEMBL9520549 0.74 CYP3A4 (0.51) S1PR1NR1I2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0523803-A1 1,2,4-Oxadiazolyl-phenoxy-alkylisoxazoles and their use as antiviral agents STERLING WINTHROP INC. (US) 1993-01-20 EP disclosed