Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | CASP3 | P42574 | 1/20 | 0.67 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | ALPG | P10696 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12201092 | 0.89 | POLB (0.53) | MAPTCASP3SENP7TDP1KMT2A | |
| SCHEMBL13020889 | 0.86 | ALDH1A1 (0.60) | MAPTCASP3SENP7TDP1KMT2A | |
| SCHEMBL9523960 | 0.85 | MAPT (0.61) | MAPTCASP3SENP7TDP1KMT2A | |
| SCHEMBL28107976 | 0.82 | MAPT (0.77) | MAPTCASP3SENP7TDP1ALPG | |
| SCHEMBL8487571 | 0.82 | ACHE (0.48) | MAPTCASP3SENP7TDP1KMT2A | |
| SCHEMBL8707905 | 0.81 | NPC1 (0.68) | MAPTCASP3SENP7KMT2AMEN1 | |
| SCHEMBL120371 | 0.78 | HTR2A (0.49) | MAPTCASP3SENP7TDP1KMT2A | |
| SCHEMBL7347858 | 0.74 | FLT3 (0.69) | MAPTCASP3SENP7TDP1ALPG | |
| SCHEMBL25054008 | 0.73 | KMT2A (0.64) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL527544 | 0.73 | KMT2A (0.71) | MAPTTDP1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354583-B1 | DC-88A derivatives | KYOWA HAKKO KOGYO KK (JP) | 1993-11-03 | — | — | EP | disclosed |
| US-5248692-A | DC-89 derivatives as anti-tumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-09-28 | — | — | US | disclosed |
| US-5214065-A | Antitumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-05-25 | — | — | US | disclosed |
| US-5117006-A | DC-88A DERIVATIVES USEFUL AS ANTITUMOR AGENTS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| US-5084468-A | Antitumor agents | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-01-28 | — | — | US | disclosed |
| EP-0461603-A1 | DC-89 derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-12-18 | — | — | EP | disclosed |
| EP-0354583-A1 | DC-88A derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-02-14 | — | — | EP | disclosed |