Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | F12 | P00748 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13020889 | 0.91 | ALDH1A1 (0.60) | POLBMAPTCASP3SENP7TDP1 | |
| SCHEMBL9523960 | 0.90 | MAPT (0.61) | MAPTCASP3SENP7TDP1KMT2A | |
| SCHEMBL9523638 | 0.89 | MAPT (0.67) | POLBMAPTCASP3SENP7TDP1 | |
| SCHEMBL655464 | 0.83 | CA12 (0.56) | POLBMAPTKMT2AMAOBMAOA | |
| SCHEMBL23258446 | 0.80 | POLB (0.59) | POLBMAPTKMT2AMAOBMAOA | |
| SCHEMBL16943491 | 0.80 | CA12 (0.52) | POLBMAPTTDP1KMT2AMAOB | |
| SCHEMBL29592689 | 0.80 | POLB (0.52) | POLBMAPTKMT2AMAOBMAOA | |
| SCHEMBL2249264 | 0.80 | POLB (0.52) | POLBMAPTKMT2AMAOBMAOA | |
| SCHEMBL654558 | 0.80 | MAOA (0.67) | POLBMAPTTDP1KMT2AMAOB | |
| SCHEMBL4001852 | 0.80 | POLB (0.69) | POLBMAPTTDP1KMT2AMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8034959-B2 | Methods of treating cancer with an antibody-drug conjugate | MEDAREX, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-8034959-B2 | Methods of treating cancer with an antibody-drug conjugate | MEDAREX, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-7977465-B2 | Peptidyl prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| US-7977465-B2 | Peptidyl prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2011-07-12 | — | — | US | disclosed |
| EP-2266986-A1 | Cytotoxins, Prodrugs, Linkers and Stabilizers useful therefor | Medarex, Inc. (US) | 2010-12-29 | — | — | EP | disclosed |
| US-RE41252-E1 | Peptidyl prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2010-04-20 | — | — | US | disclosed |
| US-RE41252-E1 | Peptidyl prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2010-04-20 | — | — | US | disclosed |
| US-20090209734-A1 | PEPTIDYL PRODRUGS AND LINKERS AND STABILIZERS USEFUL THEREFOR | MEDAREX, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090209734-A1 | PEPTIDYL PRODRUGS AND LINKERS AND STABILIZERS USEFUL THEREFOR | MEDAREX, INC. (US) | 2009-08-20 | — | — | US | disclosed |
| US-20090175888-A1 | METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE | MEDAREX, INC. (US) | 2009-07-09 | — | — | US | disclosed |
| US-7507420-B2 | Peptidyl prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7507420-B2 | Peptidyl prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2009-03-24 | — | — | US | disclosed |
| US-7498302-B2 | Disulfide prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2009-03-03 | — | — | US | disclosed |
| US-7498302-B2 | Disulfide prodrugs and linkers and stabilizers useful therefor | MEDAREX, INC. (US) | 2009-03-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090175888-A1 | METHODS OF TREATING CANCER WITH AN ANTIBODY-DRUG CONJUGATE | PDIA5, CD38, DUT | POLB 3940/4885MAPT 3373/4885CASP3 96/4885 |
| US-20090209734-A1 | PEPTIDYL PRODRUGS AND LINKERS AND STABILIZERS USEFUL THEREFOR | VIP, PIN1, PDF | POLB 3470/4885MAPT 2764/4885CASP3 593/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.