Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPE | Q05469 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 8/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 7/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524734 | 0.87 | CHRM2 (0.41) | LIPETMEM97SIGMAR1HTR1AADRA1D | |
| SCHEMBL9384884 | 0.82 | LIPE (0.40) | LIPETMEM97SIGMAR1HTR1AALDH1A1 | |
| SCHEMBL9527774 | 0.82 | SYK (0.41) | LIPESIGMAR1HTR1AADRA1DADRA1B | |
| SCHEMBL9524247 | 0.81 | HTR1A (0.38) | LIPETMEM97SIGMAR1HTR1AADRA1D | |
| SCHEMBL25819360 | 0.79 | LIPE (0.50) | LIPEALDH1A1GAANPC1RAB9A | |
| SCHEMBL4416797 | 0.72 | MEN1 (0.51) | TMEM97SIGMAR1HTR1AADRA1DADRA1B | |
| SCHEMBL3673656 | 0.71 | ALDH1A1 (0.49) | LIPEALDH1A1CTSLCTSBCTSK | |
| SCHEMBL2621408 | 0.71 | TMEM97 (0.49) | TMEM97SIGMAR1ALDH1A1GAANPC1 | |
| SCHEMBL30981534 | 0.70 | LIPE (0.47) | LIPEALDH1A1CTSLCTSBCTSK | |
| SCHEMBL3864756 | 0.70 | HTT (0.53) | LIPEALDH1A1CTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0562042-A1 | QUINOLINE, NAPHTHYRIDINE AND PYRIDOBENZOXAZINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1993-09-29 | — | — | EP | disclosed |
| US-5137892-A | Bactericides | ABBOTT LABORATORIES (US) | 1992-08-11 | — | — | US | disclosed |
| WO-1992010191-A1 | QUINOLINE, NAPHTHYRIDINE AND PYRIDOBENZOXAZINE DERIVATIVES | ABBOTT LABORATORIES (US) | 1992-06-25 | — | — | WO | disclosed |