SCHEMBL9523907

SCHEMBL9523907

CC1(C)CC(c2cccc[n+]2[O-])c2cc([N+](=O)[O-])ccc2O1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
DRD4 P21917 1/20 0.39
TLR3 O15455 1/20 0.38
SIRT2 Q8IXJ6 1/20 0.37
AKR1B1 P15121 2/20 0.36
CHRNB4 P30926 4/20 0.36
CHRNA3 P32297 4/20 0.36
MAPT P10636 3/20 0.36
HTT P42858 2/20 0.36
ALDH1A1 P00352 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.35
LMNA P02545 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
NR3C1 P04150 2/20 0.34
HIF1A Q16665 1/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
PGR P06401 1/20 0.33
AR P10275 1/20 0.33
MITF O75030 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9525177 0.88 ALDH1A1 (0.39) DRD4TLR3SIRT2AKR1B1MAPT
SCHEMBL9524833 0.83 TLR3 (0.37) DRD4TLR3SIRT2AKR1B1CHRNB4
SCHEMBL9525036 0.83 DRD4 (0.41) DRD4SIRT2HTTLMNASMN1; SMN2
SCHEMBL9523686 0.83 DRD4 (0.34) DRD4HTTALDH1A1LMNA
SCHEMBL9525203 0.82 KMT2A (0.34) AKR1B1HTTALDH1A1KMT2A
SCHEMBL8334887 0.82 OPRD1 (0.35) HTTALDH1A1SMN1; SMN2KMT2A
SCHEMBL9524652 0.81 KDM4E (0.35) DRD4
SCHEMBL9523894 0.81 ALDH1A1 (0.38) MAPTALDH1A1
SCHEMBL9523944 0.81 DRD4 (0.35) DRD4MAPTHTTALDH1A1
SCHEMBL9524946 0.81 HTR1A (0.34) DRD4MAPTSMN1; SMN2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0298452-B1 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL F. HOFFMANN-LA ROCHE AG (CH) 1993-06-30 EP claimed
US-4971982-A HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS HOFFMANN-LA ROCHE INC. (US) 1990-11-20 US claimed
US-5118694-A Hypotensive agents; treatment for cardiovascular and muscular disorders HOFFMANN-LA ROCHE INC. (US) 1992-06-02 US disclosed
US-4971982-A HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS HOFFMANN-LA ROCHE INC. (US) 1990-11-20 US disclosed