Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524652 | 0.90 | KDM4E (0.35) | DRD4TRPV1 | |
| SCHEMBL9525763 | 0.88 | ABCC9 (0.38) | DRD4TSHRMAPTSMN1; SMN2CNR1 | |
| SCHEMBL9524585 | 0.88 | ALOX5 (0.38) | DRD4TSHRTRPV1MAPTMEN1 | |
| SCHEMBL9524905 | 0.86 | DRD4 (0.33) | DRD4TRPV1MAPTCNR1CNR2 | |
| SCHEMBL9525177 | 0.84 | ALDH1A1 (0.39) | HTR1DDRD4MAPTSMN1; SMN2 | |
| SCHEMBL9523970 | 0.84 | DRD4 (0.33) | DRD4 | |
| SCHEMBL9525115 | 0.84 | DRD4 (0.33) | DRD4TSHRTRPV1MAPTSMN1; SMN2 | |
| SCHEMBL9523686 | 0.81 | DRD4 (0.34) | HTR2CDRD4TRPV1 | |
| SCHEMBL9525036 | 0.81 | DRD4 (0.41) | HTR1AHTR2CDRD4TRPV1SMN1; SMN2 | |
| SCHEMBL9525203 | 0.81 | KMT2A (0.34) | TRPV1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | claimed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| CN-1030582-A | 1-benzopyran derivatives | HOFFMANN LA ROCHE (CH) | 1989-01-25 | — | — | CN | disclosed |