Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 5/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | METAP2 | P50579 | 1/20 | 0.53 |
| ▸ | METAP1 | P53582 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SCD | O00767 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11615008 | 0.80 | ALDH1A1 (0.60) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9525692 | 0.78 | NPC1 (0.56) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9525679 | 0.77 | NPC1 (0.54) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9524877 | 0.76 | ADORA3 (0.56) | RAB9ALMNASMN1; SMN2L3MBTL1MEN1 | |
| SCHEMBL9523892 | 0.76 | HIF1A (0.53) | NPC1RAB9ALMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL11200295 | 0.74 | ALDH1A1 (0.54) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9523663 | 0.73 | KMT2A (0.53) | NPC1RAB9AALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL10662601 | 0.73 | ALDH1A1 (0.53) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL12258300 | 0.73 | FLT3 (0.60) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9525647 | 0.73 | RAB9A (0.56) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |