Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 5/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL28544352 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL28304336 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL21145215 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL21145213 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL9050228 | 0.97 | ALDH1A1 (0.83) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL6061927 | 0.95 | ALDH1A1 (0.79) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL27500370 | 0.94 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL2034627 | 0.94 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL240402 | 0.94 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL10896997 | 0.94 | ALDH1A1 (1.00) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220403197-A1 | THREE-DIMENSIONAL PRINTING WITH SCENT AGENTS | PERIDOT PRINT LLC | 2022-12-22 | — | — | US | claimed |
| WO-2021118529-A1 | THREE-DIMENSIONAL PRINTING WITH SCENT AGENTS | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2021-06-17 | — | — | WO | claimed |
| US-20060115522-A1 | Pharmaceutical composition | CIPLA LTD (IN) | 2006-06-01 | — | — | US | claimed |
| EP-1594484-A2 | PHARMACEUTICAL PATCH | Cipla Ltd. (IN) | 2005-11-16 | — | — | EP | claimed |
| WO-2004071398-A9 | PHARMACEUTICAL PATCH | CIPLA LTD (IN) | 2005-10-20 | — | — | WO | claimed |
| WO-2004071398-A2 | PHARMACEUTICAL PATCH | CIPLA LTD (IN) | 2004-08-26 | — | — | WO | claimed |
| US-20220403197-A1 | THREE-DIMENSIONAL PRINTING WITH SCENT AGENTS | PERIDOT PRINT LLC | 2022-12-22 | — | — | US | disclosed |
| CN-217293982-U | Ink jet printing apparatus | 三星显示有限公司 | 2022-08-26 | — | — | CN | disclosed |
| CN-112315023-B | Cigarette filler aggregate and electronic cigarette case | 未来科技株式会社 | 2021-12-14 | — | — | CN | disclosed |
| WO-2021118529-A1 | THREE-DIMENSIONAL PRINTING WITH SCENT AGENTS | HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P. (US) | 2021-06-17 | — | — | WO | disclosed |
| CN-112315023-A | Cigarette filler aggregate and electronic cigarette case | 株式会社东亚产业 | 2021-02-05 | — | — | CN | disclosed |
| CN-110141006-B | Cigarette filler aggregate and electronic cigarette case | 株式会社东亚产业 | 2020-11-24 | — | — | CN | disclosed |
| US-9783571-B2 | Isolation of cysteine containing peptides | MARTIN WARHAM LANCE (US) | 2017-10-10 | — | — | US | disclosed |
| US-20060115522-A1 | Pharmaceutical composition | CIPLA LTD (IN) | 2006-06-01 | — | — | US | disclosed |
| EP-1594484-A2 | PHARMACEUTICAL PATCH | Cipla Ltd. (IN) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004071398-A9 | PHARMACEUTICAL PATCH | CIPLA LTD (IN) | 2005-10-20 | — | — | WO | disclosed |
| WO-2004071398-A2 | PHARMACEUTICAL PATCH | CIPLA LTD (IN) | 2004-08-26 | — | — | WO | disclosed |
| EP-1231948-A1 | A PROPELLANT FREE SPRAY-ON SKIN PATCH COMPOSITION FOR IMPROVING WOUND HEALING AND FOR DRUG ADMINISTRATION | Ever Power Holding Inc. (VG) | 2002-08-21 | — | — | EP | disclosed |
| WO-2001037890-A1 | A PROPELLANT FREE SPRAY-ON SKIN PATCH COMPOSITION FOR IMPROVING WOUND HEALING AND FOR DRUG ADMINISTRATION | EVER POWER HOLDING INC (VG) | 2001-05-31 | — | — | WO | disclosed |
| EP-0535237-A1 | COMPOSITION FOR RELIEVING SKIN IRRITATION AND EXTERNAL PREPARATION FOR PERCUTANEOUS ADMINSTRATION CONTAINING THE SAME | Hisamitsu Pharmaceutical Co., Inc. (JP) | 1993-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060115522-A1 | Pharmaceutical composition | TSLP, CUTA, IL2 | MEN1 2111/4885ALDH1A1 3437/4885HMGCR 255/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.