Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 2/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525700 | 0.78 | KDM4E (0.39) | METAP2KCNH2OPRD1CYP1A2CYP2C19 | |
| SCHEMBL27354166 | 0.74 | METAP2 (0.37) | METAP2CYP2A6KCNH2ADRA1AKMT2A | |
| SCHEMBL769104 | 0.71 | NISCH (0.40) | KCNH2OPRD1ADRA1AKMT2ACYP2C19 | |
| SCHEMBL6535545 | 0.69 | ALDH1A1 (0.41) | KCNH2OPRD1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL4160810 | 0.69 | CYP2A6 (0.52) | METAP2CYP2A6ADRA1AKMT2ACYP1A2 | |
| SCHEMBL9523520 | 0.68 | CCNC (0.40) | KCNH2OPRD1BACE1 | |
| SCHEMBL9845357 | 0.67 | OPRD1 (0.45) | KCNH2OPRD1TDP1MAPT | |
| SCHEMBL9527612 | 0.67 | NPC1 (0.44) | METAP2KMT2ACYP1A2GAAL3MBTL1 | |
| SCHEMBL29924154 | 0.66 | CYP2A6 (0.61) | METAP2CYP2A6KMT2APDK2GAA | |
| SCHEMBL31252534 | 0.66 | CYP2A6 (0.61) | METAP2CYP2A6KMT2APDK2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| CN-1030582-A | 1-benzopyran derivatives | HOFFMANN LA ROCHE (CH) | 1989-01-25 | — | — | CN | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |