Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 15/20 | 0.40 |
| ▸ | CDK8 | P49336 | 15/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 13/20 | 0.40 |
| ▸ | CDK19 | Q9BWU1 | 7/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525775 | 0.79 | RARA (0.41) | CCNCCDK8HASPINCDK19 | |
| Hydrochloric Acid SCHEMBL9527636 | 0.78 | RARA (0.40) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL9378940 | 0.76 | SMN1; SMN2 (0.30) | CCNCCDK8HASPINCDK19 | |
| SCHEMBL9525700 | 0.71 | KDM4E (0.39) | KCNH2OPRD1CYP2D6 | |
| SCHEMBL27313326 | 0.70 | ALDH1A1 (0.37) | KCNH2OPRD1 | |
| SCHEMBL9524666 | 0.68 | METAP2 (0.37) | KCNH2BACE1OPRD1 | |
| SCHEMBL769104 | 0.68 | NISCH (0.40) | KCNH2OPRD1CYP2D6 | |
| SCHEMBL12023184 | 0.68 | IDO1 (0.48) | CCNCCDK8HASPINMAOAMAOB | |
| SCHEMBL9525977 | 0.67 | OPRD1 (0.37) | OPRD1 | |
| SCHEMBL12365910 | 0.67 | RARA (0.51) | KCNH2OPRD1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | claimed |
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |