Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525648 | 0.83 | RIPK1 (0.47) | NPC1RAB9ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL9527385 | 0.81 | MEN1 (0.52) | LMNAALDH1A1MAPTHPGDPOLB | |
| SCHEMBL9525587 | 0.81 | ADORA3 (0.47) | NPC1RAB9ASMN1; SMN2MAPTPOLB | |
| SCHEMBL9524703 | 0.77 | GPR27 (0.46) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9527884 | 0.74 | POLB (0.45) | NPC1RAB9ASMN1; SMN2MAPTPOLB | |
| SCHEMBL9524877 | 0.74 | ADORA3 (0.56) | RAB9ALMNASMN1; SMN2MAPTHPGD | |
| SCHEMBL9525559 | 0.73 | EGFR (0.41) | LMNAALDH1A1SMN1; SMN2MAPTHPGD | |
| SCHEMBL9524562 | 0.72 | ADORA3 (0.59) | NPC1RAB9ALMNASMN1; SMN2MAPT | |
| SCHEMBL9524321 | 0.72 | FLT3 (0.57) | NPC1RAB9AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9525781 | 0.72 | FLT3 (0.51) | NPC1RAB9ALMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |