Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524520 | 0.82 | LMNA (0.51) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL9524826 | 0.81 | NPC1 (0.47) | KMT2AHPGDALDH1A1MAPTLMNA | |
| SCHEMBL9524970 | 0.79 | HSP90AA1 (0.47) | MEN1KMT2AALDH1A1MAPTPOLB | |
| SCHEMBL9527944 | 0.77 | NSD2 (0.50) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL9525735 | 0.77 | EGLN1 (0.49) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL9525648 | 0.75 | RIPK1 (0.47) | MEN1KMT2AHPGDALDH1A1MAPT | |
| SCHEMBL9523469 | 0.75 | EGLN1 (0.45) | MEN1KMT2AALDH1A1MAPTGAA | |
| SCHEMBL9525718 | 0.72 | TP53 (0.47) | MEN1KMT2AHPGDCYP1A2CYP2C19 | |
| SCHEMBL9524641 | 0.72 | ALDH1A1 (0.45) | KMT2AALDH1A1MAPTCYP1A2CYP2C19 | |
| SCHEMBL9524438 | 0.72 | MEN1 (0.50) | MEN1KMT2AHPGDLMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |