Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.39 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.39 |
| ▸ | NEK10 | Q6ZWH5 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524674 | 0.82 | KMT2A (0.45) | HTTHPGDMEN1KMT2ALCK | |
| SCHEMBL9527775 | 0.75 | CYP1A2 (0.47) | TSHRHPGDLCKMAP2K3MAP2K6 | |
| SCHEMBL31371878 | 0.74 | LCK (0.51) | ALDH1A1TSHRHPGDMEN1KMT2A | |
| SCHEMBL7706331 | 0.74 | LCK (0.51) | ALDH1A1TSHRHPGDMEN1KMT2A | |
| SCHEMBL9525627 | 0.74 | LCK (0.40) | HTTMEN1KMT2ALCKMAP2K3 | |
| SCHEMBL9525025 | 0.74 | ALDH1A1 (0.44) | ALDH1A1 | |
| SCHEMBL9524656 | 0.73 | CYP1A2 (0.43) | TSHRHPGD | |
| SCHEMBL9523543 | 0.72 | MEN1 (0.44) | TSHRHPGDMEN1KMT2ANPC1 | |
| SCHEMBL10861354 | 0.71 | KDM4E (0.51) | ALDH1A1TSHRGLATP53HPGD | |
| SCHEMBL9525642 | 0.70 | KDM4E (0.51) | ALDH1A1TSHRHTTTP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |