Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 5/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525763 | 0.93 | ABCC9 (0.38) | DRD4ABCC9CNR2CNR1NPC1 | |
| SCHEMBL9525115 | 0.92 | DRD4 (0.33) | DRD4ABCC9TRPV1MAPT | |
| SCHEMBL9525177 | 0.89 | ALDH1A1 (0.39) | DRD4NPC1RAB9AMAPT | |
| SCHEMBL9523970 | 0.89 | DRD4 (0.33) | DRD4 | |
| SCHEMBL9524652 | 0.87 | KDM4E (0.35) | DRD4TRPV1 | |
| SCHEMBL9524946 | 0.86 | HTR1A (0.34) | DRD4CNR2CNR1TRPV1MAPT | |
| SCHEMBL9524585 | 0.84 | ALOX5 (0.38) | DRD4NPC1RAB9ATRPV1NPSR1 | |
| SCHEMBL9628082 | 0.78 | ABCC9 (0.34) | ABCC9NPC1RAB9ATRPV1NPSR1 | |
| SCHEMBL9525036 | 0.78 | DRD4 (0.41) | DRD4TRPV1NPSR1 | |
| SCHEMBL9523686 | 0.78 | DRD4 (0.34) | DRD4TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | claimed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |