Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CASR | P41180 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9525649 | 0.92 | ADRA2A (0.32) | MEN1KMT2AKDM4EPOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL9524127 | 0.89 | CHRM4 (0.36) | KMT2AKDM4ECHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL9525722 | 0.84 | NPSR1 (0.42) | MEN1KMT2ANPSR1GAALMNA | |
| SCHEMBL9529286 | 0.83 | NPC1 (0.41) | MEN1KMT2ANPSR1GAAKDM4E | |
| Iodide SCHEMBL9407503 | 0.82 | KMT2A (0.34) | MEN1KMT2ALMNAPOLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL9525961 | 0.82 | CHRNB2 (0.42) | POLBMAPT | |
| Hydrochloric Acid SCHEMBL9525154 | 0.82 | MEN1 (0.38) | MEN1KMT2AKDM4ESMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9525253 | 0.82 | MEN1 (0.33) | MEN1KMT2AALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL9525272 | 0.81 | TSHR (0.38) | MEN1KMT2ANPSR1KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL9525444 | 0.80 | AGTR1 (0.31) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0301751-B1 | PYRIDINIUM DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1993-03-10 | — | — | EP | disclosed |
| US-4962113-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD (JP) | 1990-10-09 | — | — | US | disclosed |
| EP-0301751-A1 | Pyridinium derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1989-02-01 | — | — | EP | disclosed |