Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.32 |
| ▸ | HPGD | P15428 | 6/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9366088 | 0.85 | KDM4E (0.31) | KDM4EALDH1A1HPGDTP53MAPT | |
| SCHEMBL9526560 | 0.85 | ALDH1A1 (0.33) | KDM4EALDH1A1HPGDTP53L3MBTL1 | |
| Dimethylamine SCHEMBL9526570 | 0.70 | CHRM4 (0.44) | KDM4EALDH1A1HPGDL3MBTL1MAPT | |
| SCHEMBL9365819 | 0.69 | GAA (0.32) | — | |
| SCHEMBL9368107 | 0.69 | ALDH1A1 (0.46) | KDM4EALDH1A1HPGDTP53MAPT | |
| Diethylamine SCHEMBL9525434 | 0.69 | CHRM4 (0.41) | KDM4EALDH1A1HPGDL3MBTL1MAPT | |
| SCHEMBL9367169 | 0.67 | ALDH1A1 (0.40) | KDM4EALDH1A1HPGDTP53L3MBTL1 | |
| SCHEMBL3055938 | 0.66 | ALDH1A1 (0.33) | KDM4EALDH1A1HPGDTP53L3MBTL1 | |
| SCHEMBL9526562 | 0.64 | CYP2D6 (0.45) | KDM4EALDH1A1MAPTKMT2ANPSR1 | |
| SCHEMBL9365797 | 0.62 | CISD2 (0.31) | KDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297697-B1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1993-12-29 | — | — | EP | disclosed |
| US-4904686-A | 3-ALKOXYTHIOPHENE-2-CARBOXAMIDES; CENTRAL NERVOUS SYSTEM DISORDERS | LILLY INDUSTRIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |