Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Diethylamine SCHEMBL9525434 | 0.92 | CHRM4 (0.41) | CHRM4HPGDNPC1KDM4EALDH1A1 | |
| Dimethylamine SCHEMBL9365835 | 0.82 | CHRM4 (0.41) | CHRM4HPGDNPC1KDM4EALDH1A1 | |
| SCHEMBL9526562 | 0.78 | CYP2D6 (0.45) | NPC1KDM4EALDH1A1RAB9AMAPT | |
| Diethylamine SCHEMBL9366095 | 0.76 | CHRM4 (0.38) | CHRM4HPGDNPC1KDM4EALDH1A1 | |
| SCHEMBL9368107 | 0.74 | ALDH1A1 (0.46) | HPGDKDM4EALDH1A1HSD17B10RAB9A | |
| SCHEMBL9367169 | 0.72 | ALDH1A1 (0.40) | HPGDKDM4EALDH1A1L3MBTL1HSD17B10 | |
| SCHEMBL7217566 | 0.71 | HPGD (0.41) | CHRM4HPGDNPC1KDM4EALDH1A1 | |
| SCHEMBL3055938 | 0.71 | ALDH1A1 (0.33) | HPGDKDM4EALDH1A1L3MBTL1MAPT | |
| SCHEMBL9365797 | 0.71 | CISD2 (0.31) | KDM4EALDH1A1L3MBTL1CISD2 | |
| SCHEMBL9525428 | 0.70 | KDM4E (0.33) | HPGDKDM4EALDH1A1L3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297697-B1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1993-12-29 | — | — | EP | disclosed |
| US-4904686-A | 3-ALKOXYTHIOPHENE-2-CARBOXAMIDES; CENTRAL NERVOUS SYSTEM DISORDERS | LILLY INDUSTRIES LIMITED (GB) | 1990-02-27 | — | — | US | disclosed |
| EP-0297697-A1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1989-01-04 | — | — | EP | disclosed |