Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 8/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KCNJ6 | P48051 | 2/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 2/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522526 | 0.98 | IKBKB (0.38) | RIPK1IKBKBTP53LMNAALDH1A1 | |
| SCHEMBL9316080 | 0.96 | TP53 (0.37) | RIPK1IKBKBTP53LMNAMAPT | |
| SCHEMBL9525898 | 0.91 | MAPT (0.40) | RIPK1IKBKBTP53LMNAALDH1A1 | |
| SCHEMBL9522374 | 0.91 | RIPK1 (0.39) | RIPK1TP53LMNAALDH1A1KCNJ6 | |
| SCHEMBL9525567 | 0.91 | KCNJ6 (0.38) | LMNAALDH1A1KCNJ6KCNJ5KCNJ3 | |
| SCHEMBL9523720 | 0.89 | MEN1 (0.37) | TP53LMNAALDH1A1MAPTRAB9A | |
| SCHEMBL9523934 | 0.89 | IKBKB (0.37) | RIPK1IKBKBTP53LMNAALDH1A1 | |
| SCHEMBL9522532 | 0.89 | MAPT (0.39) | RIPK1IKBKBTP53LMNAALDH1A1 | |
| SCHEMBL9168566 | 0.88 | IKBKB (0.41) | RIPK1IKBKBLMNAALDH1A1MAPT | |
| SCHEMBL9832532 | 0.87 | ALDH1A1 (0.42) | RIPK1IKBKBTP53LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420883-B1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5166152-A | Immunostimulants, bactericides, viricides, antitumor agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-11-24 | — | — | US | disclosed |
| EP-0420883-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1991-04-10 | — | — | EP | disclosed |
| WO-1989012638-A1 | TRICYCLIC 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |