Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CCKBR | P32239 | 11/20 | 0.54 |
| ▸ | CCKAR | P32238 | 4/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ALB | P02768 | 1/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526278 | 1.00 | MEN1 (0.58) | MEN1KMT2AALDH1A1CCKBRCCKAR | |
| SCHEMBL10812464 | 0.84 | LMNA (0.74) | MEN1KMT2ACCKBRCHRM1LMNA | |
| SCHEMBL9526940 | 0.82 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL9526945 | 0.82 | CCKBR (0.57) | CCKBRCCKAR | |
| SCHEMBL644829 | 0.81 | MEN1 (0.58) | MEN1KMT2AALDH1A1CCKBRCCKAR | |
| SCHEMBL11464107 | 0.81 | MEN1 (0.58) | MEN1KMT2AALDH1A1CCKBRCCKAR | |
| SCHEMBL4700911 | 0.81 | MEN1 (0.58) | MEN1KMT2AALDH1A1CCKBRCCKAR | |
| SCHEMBL4704741 | 0.81 | MEN1 (0.58) | MEN1KMT2AALDH1A1CCKBRCCKAR | |
| SCHEMBL3417103 | 0.81 | GABRA1 (0.71) | MEN1KMT2AALDH1A1CCKBRCCKAR | |
| SCHEMBL642305 | 0.81 | MEN1 (0.58) | MEN1KMT2AALDH1A1CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167919-B1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5004741-A | Cholecystokinin(CCK); Treating Disorders Of The Gastrointestinal Tract, Central Nervous System And Of The Appetite Of Animals | MERCK & CO., INC. (US) | 1991-04-02 | — | — | US | disclosed |
| US-4820834-A | Benzodiazepine analogs | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0284256-A1 | Benzodiazepine analogs | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |