SCHEMBL644829

SCHEMBL644829

N[C@H]1N=C(c2ccccc2)c2ccccc2NC1=O

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.58
ALDH1A1 P00352 1/20 0.58
KMT2A Q03164 1/20 0.58
CCKBR P32239 10/20 0.55
CCKAR P32238 5/20 0.54
HDAC1 Q13547 1/20 0.54
CHRM1 P11229 1/20 0.54
GABRA1 P14867 2/20 0.51
GABRG2 P18507 2/20 0.51
GABRB3 P28472 2/20 0.51
GABRA5 P31644 2/20 0.51
GABRA3 P34903 2/20 0.51
GABRA2 P47869 2/20 0.51
GABRB2 P47870 2/20 0.51
GABRP O00591 1/20 0.50
GABRD O14764 1/20 0.50
GABRB1 P18505 1/20 0.50
GABRA4 P48169 1/20 0.50
GABRE P78334 1/20 0.50
GABRA6 Q16445 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL642305 1.00 MEN1 (0.58) MEN1ALDH1A1KMT2ACCKBRCCKAR
SCHEMBL4700911 1.00 MEN1 (0.58) MEN1ALDH1A1KMT2ACCKBRCCKAR
Bromide SCHEMBL8422518 0.98 MEN1 (0.56) MEN1ALDH1A1KMT2ACCKBRCCKAR
Bromide SCHEMBL8422516 0.97 MEN1 (0.55) MEN1ALDH1A1KMT2ACCKBRCCKAR
SCHEMBL8218620 0.89 CCKBR (0.60) MEN1ALDH1A1KMT2ACCKBRCCKAR
SCHEMBL2526769 0.88 CCKBR (0.56) MEN1ALDH1A1KMT2ACCKBRCCKAR
SCHEMBL18315499 0.88 MEN1 (0.50) MEN1ALDH1A1KMT2ACCKBRCCKAR
SCHEMBL15629440 0.88 MEN1 (0.50) MEN1ALDH1A1KMT2ACCKBRCCKAR
SCHEMBL19988836 0.88 GABRA1 (0.51) MEN1ALDH1A1KMT2ACCKBRCCKAR
SCHEMBL6005722 0.85 ALDH1A1 (0.50) MEN1ALDH1A1KMT2ACCKBRCCKAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 171 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12384764-B2 Pharmaceutical compounds PFIZER INC. (US) 2025-08-12 US disclosed
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-05-13 US disclosed
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2025-04-08 US disclosed
CN-114787155-B Pharmaceutical compounds 辉瑞公司 2025-02-28 CN disclosed
US-12227507-B2 Pharmaceutical compounds PFIZER INC. (US) 2025-02-18 US disclosed
CN-114761397-B Benzodiazepine derivatives for the treatment of Respiratory Syncytial Virus (RSV) infection 辉瑞公司 2024-11-05 CN disclosed
US-20240360117-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS ENANTA PHARM INC (US) 2024-10-31 US disclosed
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors ENANTA PHARM INC (US) 2024-10-31 US disclosed
US-20240173332-A1 BENZODIAZEPINES FOR TREATING OR PREVENTING RESPIRATORY SYNCYTIAL VIRUS INFECTION PFIZER INC. (US) 2024-05-30 US disclosed
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors ENANTA PHARMACEUTICALS, INC. (US) 2024-04-09 US disclosed
EP-0434369-A1 New benzodiazepine analogs MERCK & CO. INC. (US) 1991-06-26 EP disclosed
EP-0434364-A2 Benzodiazepine analogs for treating panic syndrome and for directly inducing analgesia MERCK & CO. INC. (US) 1991-06-26 EP disclosed
EP-0434360-A1 New benziodiazepine analogs MERCK & CO. INC. (US) 1991-06-26 EP disclosed
EP-0421802-A2 3-substituted-1,4-benzodiazepines useful as oxytocin antagonists MERCK & CO. INC. (US) 1991-04-10 EP disclosed
US-5004741-A Cholecystokinin(CCK); Treating Disorders Of The Gastrointestinal Tract, Central Nervous System And Of The Appetite Of Animals MERCK & CO., INC. (US) 1991-04-02 US disclosed
US-4970207-A Benzodiazepine derivatives FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1990-11-13 US disclosed
EP-0349949-A2 Benzodiazepine derivatives FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-01-10 EP disclosed
US-4820834-A Benzodiazepine analogs MERCK & CO., INC. (US) 1989-04-11 US disclosed
EP-0284256-A1 Benzodiazepine analogs MERCK & CO. INC. (US) 1988-09-28 EP disclosed
EP-0167919-A2 Benzodiazepine derivatives and pharmaceutical compositions containing them MERCK & CO. INC. (US) 1986-01-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240173332-A1 BENZODIAZEPINES FOR TREATING OR PREVENTING RESPIRATORY SYNCYTIAL VIRUS INFECTION GABRA3, GABRA6, GABRA1 MEN1 3936/4885ALDH1A1 2754/4885KMT2A 2739/4885
US-12227507-B2 Pharmaceutical compounds CHRNA6, GABRA6, CHRNA7 MEN1 3324/4885ALDH1A1 3480/4885KMT2A 3557/4885
US-20240360155-A1 Benzodiazepine Derivatives as RSV Inhibitors GABRA5, GABRA1, GABBR2 MEN1 3463/4885ALDH1A1 621/4885KMT2A 1493/4885
US-11952389-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 MEN1 3463/4885ALDH1A1 621/4885KMT2A 1493/4885
US-12297209-B2 Benzodiazepine derivatives as RSV inhibitors GABRA5, GABRA1, GABBR2 MEN1 3463/4885ALDH1A1 621/4885KMT2A 1493/4885
US-20240360117-A1 BENZODIAZEPINE DERIVATIVES AS RSV INHIBITORS GABRA5, GABRA1, GABBR2 MEN1 3463/4885ALDH1A1 621/4885KMT2A 1493/4885
US-12268694-B2 Combination pharmaceutical agents as RSV inhibitors ACE, ACE2, SPCS3 MEN1 3954/4885ALDH1A1 4172/4885KMT2A 3282/4885
US-12384764-B2 Pharmaceutical compounds CNR1, HRH4, GABRA1 MEN1 2262/4885ALDH1A1 2411/4885KMT2A 3475/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.