Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSPA8 | P11142 | 7/20 | 0.82 |
| ▸ | HSPA5 | P11021 | 3/20 | 0.82 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.82 |
| ▸ | SLC28A2 | O43868 | 10/20 | 0.71 |
| ▸ | FBP1 | P09467 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6671399 | 1.00 | HSPA8 (0.82) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL30023025 | 1.00 | HSPA8 (0.82) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL952636 | 1.00 | HSPA8 (0.82) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL6760673 | 0.90 | HSPA8 (1.00) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL6760675 | 0.90 | HSPA8 (1.00) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL6685814 | 0.89 | HSPA8 (0.65) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL6762443 | 0.88 | FBP1 (0.79) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL6762435 | 0.88 | FBP1 (0.79) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL13127208 | 0.88 | HSPA8 (0.80) | HSPA8HSPA5RXFP1SLC28A2FBP1 | |
| SCHEMBL6763143 | 0.88 | HSPA8 (0.80) | HSPA8HSPA5RXFP1SLC28A2FBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8637485-B2 | 5′,-substituted adenosynes preparation thereof and use as inhibitors of S-adenosylmethionine decarboxylase | SOUTHERN RESEARCH INSTITUTE (US) | 2014-01-28 | — | — | US | disclosed |
| EP-2574616-A2 | 5'-substituted adenosynes, preparation thereof and use as inhibitors of s-adenosylmethionine decarboxylase. | Southern Research Institute (US) | 2013-04-03 | — | — | EP | disclosed |
| US-20110009354-A1 | 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-01-13 | — | — | US | disclosed |
| CN-101842008-A | 5' -substituted adenosines, production thereof and use thereof as inhibitors of S-adenosylmethionine decarboxylase | UNIV CORNELL | 2010-09-22 | — | — | CN | disclosed |
| EP-2170057-A1 | 5'-SUBSTITUTED ADENOSYNES, PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | Southern Research Institute (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009018541-A1 | 5'-SUBSTITUTED ADENOSYNES, PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | SOUTHERN RESEARCH INSTITUTE (US) | 2009-02-05 | — | — | WO | disclosed |
| US-5965106-A | ADMINISTERING TARGETING MOIETY COUPLED TO AFFINITY COMPONENT, WHEREIN TARGETING MOIETY HAS AFFINITY FOR BINDING SITES IN TARGET AREA, AND BINDING PARTNER TO AFFINITY COMPONENT COUPLED TO FUNCTIONAL MOIETY TO LOCALIZE FUNCTIONAL MOIETY IN TARGET | PERIMMUNE HOLDINGS, INC. (US) | 1999-10-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009354-A1 | 5',-SUBSTITUTED ADENOSYNES PREPARATION THEREOF AND USE AS INHIBITORS OF S-ADENOSYLMETHIONINE DECARBOXYLASE | AMD1, ADA, MTAP | HSPA8 2018/4885HSPA5 4806/4885RXFP1 4810/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.