Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | CA12 | O43570 | 4/20 | 0.64 |
| ▸ | CA9 | Q16790 | 4/20 | 0.64 |
| ▸ | CA1 | P00915 | 2/20 | 0.64 |
| ▸ | CA2 | P00918 | 2/20 | 0.64 |
| ▸ | CA4 | P22748 | 2/20 | 0.64 |
| ▸ | CA6 | P23280 | 2/20 | 0.64 |
| ▸ | CA5A | P35218 | 2/20 | 0.64 |
| ▸ | CA7 | P43166 | 2/20 | 0.64 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.61 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.61 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12530409 | 0.88 | MEN1 (0.79) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL1928662 | 0.85 | CA12 (0.85) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL6243996 | 0.85 | CA12 (0.85) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL9486456 | 0.84 | TP53 (1.00) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL12530476 | 0.83 | KMT2A (0.71) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL6241750 | 0.82 | LMNA (0.80) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL28779264 | 0.82 | TP53 (0.71) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL4106913 | 0.82 | RAB9A (0.73) | KMT2AMEN1LMNAALDH1A1RAB9A | |
| Ly-181984 SCHEMBL4612056 | 0.81 | RECQL (0.74) | KMT2AMEN1TP53LMNAALDH1A1 | |
| SCHEMBL1395600 | 0.81 | CA12 (0.78) | KMT2AMEN1TP53LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8703749-B2 | Compositions and methods for treating Friedreich's Ataxia | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2014-04-22 | — | — | US | disclosed |
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | FRATAGENE THERAPEUTICS S.R.L. (IT) | 2013-05-02 | — | — | US | disclosed |
| EP-0166615-B1 | IMPROVEMENTS IN OR RELATING TO BENZENESULFONAMIDO DERIVATIVES | ELI LILLY AND COMPANY (US) | 1993-05-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109658-A1 | COMPOSITIONS AND METHODS FOR TREATING FRIEDREICH'S ATAXIA | ATXN2, ATXN2L, ATXN10 | KMT2A 1775/4885MEN1 3597/4885TP53 4321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.