SCHEMBL9526641

SCHEMBL9526641

N#Cc1cnn(-c2ccc(C(F)(F)F)cc2Cl)c1Br

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.41
ALDH1A1 P00352 1/20 0.41
AR P10275 5/20 0.38
MRGPRX4 Q96LA9 3/20 0.36
P2RX3 P56373 2/20 0.35
P2RX2 Q9UBL9 2/20 0.35
RXRA P19793 1/20 0.35
RXRB P28702 1/20 0.35
RXRG P48443 1/20 0.35
FFAR2 O15552 1/20 0.35
MARS1 P56192 1/20 0.34
TSHR P16473 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
ACHE P22303 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
GABRP O00591 1/20 0.33
GABRD O14764 1/20 0.33
GABRA1 P14867 1/20 0.33
GABRB1 P18505 1/20 0.33
GABRG2 P18507 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10554795 0.87 KDM4E (0.43) KDM4EALDH1A1ARMRGPRX4P2RX3
SCHEMBL9526287 0.85 KMT2A (0.47) KDM4EALDH1A1ARFFAR2TSHR
SCHEMBL10769810 0.83 GABRB3 (0.45) KDM4EALDH1A1SMN1; SMN2ACHEGABRP
SCHEMBL10610136 0.82 RXRA (0.44) KDM4ERXRARXRBRXRGL3MBTL1
SCHEMBL10737240 0.82 KDM4E (0.38) KDM4EALDH1A1ARMRGPRX4P2RX3
SCHEMBL9527278 0.81 GABRP (0.41) KDM4EALDH1A1ARMRGPRX4FFAR2
SCHEMBL10848951 0.81 PKM (0.42) KDM4EALDH1A1ARMRGPRX4P2RX3
SCHEMBL10737936 0.81 CHRM5 (0.35) ARRXRARXRBRXRGL3MBTL1
Methane SCHEMBL10737246 0.81 KDM4E (0.39) KDM4EALDH1A1ARMRGPRX4P2RX3
SCHEMBL9527004 0.80 KDM4E (0.38) KDM4EALDH1A1ARMRGPRX4RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4804398-A 1-aryl-4-cyano-5-halogenopyrazoles, composition containing them, and method of using them as selective herbicides BAYER AKTIENGESELLSCHAFT (DE) 1989-02-14 US claimed
EP-0257296-B1 4-CYANO(NITRO)-5-OXY(THIO)-PYRAZOLE DERIVATIVES BAYER AG (DE) 1993-05-12 EP disclosed
US-4770692-A 4-cyano(nitro)-5-oxy(thio)-pyrazole derivatives, composition containing them, and herbicidal and plant growth regulating methods of using them BAYER AKTIENGESELLSCHAFT (DE) 1988-09-13 US disclosed
EP-0257296-A1 4-Cyano(nitro)-5-oxy(thio)-pyrazole derivatives BAYER AG (DE) 1988-03-02 EP disclosed
US-4685957-A PLANT GROWTH REGULATORS BAYER AKTIENGESELLSCHAFT (DE) 1987-08-11 US disclosed
EP-0212354-A2 1-Aryl pyrazoles BAYER AG (DE) 1987-03-04 EP disclosed