Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 4/20 | 0.53 |
| ▸ | IDO1 | P14902 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526098 | 1.00 | CCKBR (0.53) | CCKBRIDO1GSK3BTNFKMT2A | |
| SCHEMBL13981271 | 0.72 | ATM (0.48) | KMT2AMEN1 | |
| SCHEMBL11677969 | 0.71 | CCKBR (0.48) | CCKBRKMT2AMEN1 | |
| SCHEMBL6038005 | 0.71 | GSK3B (0.72) | CCKBRIDO1GSK3BKMT2ATACR2 | |
| SCHEMBL6038011 | 0.71 | GSK3B (0.72) | CCKBRIDO1GSK3BKMT2ATACR2 | |
| SCHEMBL838519 | 0.70 | IDO1 (0.75) | IDO1GSK3BTNFKMT2ATACR2 | |
| SCHEMBL28884409 | 0.70 | IDO1 (0.75) | IDO1GSK3BTNFKMT2ATACR2 | |
| Potassium SCHEMBL837807 | 0.69 | IDO1 (0.73) | IDO1GSK3BTNFKMT2ATACR2 | |
| SCHEMBL837806 | 0.69 | IDO1 (0.73) | IDO1GSK3BTNFKMT2ATACR2 | |
| SCHEMBL1623970 | 0.69 | ATM (0.46) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167919-B1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | claimed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | claimed |
| EP-0167919-B1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | disclosed |
| US-5004741-A | Cholecystokinin(CCK); Treating Disorders Of The Gastrointestinal Tract, Central Nervous System And Of The Appetite Of Animals | MERCK & CO., INC. (US) | 1991-04-02 | — | — | US | disclosed |
| US-4820834-A | Benzodiazepine analogs | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0284256-A1 | Benzodiazepine analogs | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |