Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527469 | 0.95 | NPC1 (0.35) | NPC1RAB9ASLC6A4ROCK2GABRA1 | |
| SCHEMBL9527468 | 0.94 | B3GAT3 (0.35) | RAB9A | |
| SCHEMBL9527712 | 0.92 | NPC1 (0.35) | NPC1RAB9AROCK2FFAR1GPR84 | |
| SCHEMBL9526771 | 0.92 | NPC1 (0.34) | NPC1RAB9ASLC6A4ROCK2FFAR1 | |
| SCHEMBL9526764 | 0.90 | NPC1 (0.37) | NPC1RAB9AROCK2SMN1; SMN2TSHR | |
| SCHEMBL9527749 | 0.89 | HTR1D (0.35) | RAB9ASLC6A4GABRA1GABRB2ALDH1A1 | |
| SCHEMBL9528145 | 0.88 | KDM2B (0.35) | NPC1RAB9ASLC6A4FFAR1GPR84 | |
| SCHEMBL9527280 | 0.86 | B3GAT3 (0.34) | RAB9A | |
| SCHEMBL9527214 | 0.85 | HTR7 (0.34) | RAB9AROCK2GPR84SMN1; SMN2ALDH1A1 | |
| SCHEMBL9527270 | 0.85 | MEN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337767-B1 | CYCLIC AMIDES | ICI AMERICAS INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| US-5047402-A | Leukotriene Antagonists | ICI AMERICAS INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0337767-A1 | Cyclic amides | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |