Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 4/20 | 0.34 |
| ▸ | HTR1D | P28221 | 2/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 3/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526686 | 0.95 | NPC1 (0.36) | NPC1RAB9ASLC6A4ROCK2GABRA1 | |
| SCHEMBL9527749 | 0.94 | HTR1D (0.35) | RAB9ASLC6A4KDM2BHTR1BHTR1D | |
| SCHEMBL9527468 | 0.89 | B3GAT3 (0.35) | RAB9AHTR1A | |
| SCHEMBL9527712 | 0.89 | NPC1 (0.35) | NPC1RAB9AKDM2BHTR1AROCK2 | |
| SCHEMBL9526771 | 0.89 | NPC1 (0.34) | NPC1RAB9ASLC6A4KDM2BROCK2 | |
| SCHEMBL9526915 | 0.86 | CYSLTR1 (0.40) | — | |
| SCHEMBL9528145 | 0.85 | KDM2B (0.35) | NPC1RAB9ASLC6A4KDM2BTSHR | |
| SCHEMBL9526764 | 0.85 | NPC1 (0.37) | NPC1RAB9AMTNR1AMTNR1BROCK2 | |
| SCHEMBL9877878 | 0.85 | SLC6A4 (0.35) | NPC1RAB9ASLC6A4KDM2BMTNR1A | |
| SCHEMBL9527280 | 0.84 | B3GAT3 (0.34) | RAB9AKDM2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337767-B1 | CYCLIC AMIDES | ICI AMERICAS INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| US-5047402-A | Leukotriene Antagonists | ICI AMERICAS INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0337767-A1 | Cyclic amides | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |