Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527712 | 0.95 | NPC1 (0.35) | NPC1RAB9AROCK2FFAR1GPR84 | |
| SCHEMBL9527214 | 0.94 | HTR7 (0.34) | RAB9AROCK2GPR84KDM4EMAPK1 | |
| SCHEMBL9526686 | 0.92 | NPC1 (0.36) | NPC1RAB9AROCK2FFAR1GPR84 | |
| SCHEMBL9528145 | 0.89 | KDM2B (0.35) | NPC1RAB9AFFAR1GPR84TSHR | |
| SCHEMBL9527280 | 0.89 | B3GAT3 (0.34) | RAB9AKDM2B | |
| SCHEMBL9527469 | 0.89 | NPC1 (0.35) | NPC1RAB9AROCK2TSHRKDM2B | |
| SCHEMBL9526830 | 0.86 | NPC1 (0.35) | NPC1RAB9AROCK2TSHRKDM2B | |
| SCHEMBL9527468 | 0.85 | B3GAT3 (0.35) | RAB9A | |
| SCHEMBL9526614 | 0.85 | PLA2G4A (0.39) | MAPTMAPK1MEN1KMT2A | |
| SCHEMBL9528111 | 0.83 | KDM2B (0.34) | GPR84KDM2BKDM4EGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337767-B1 | CYCLIC AMIDES | ICI AMERICAS INC. (US) | 1993-01-13 | — | — | EP | disclosed |
| US-5047402-A | Leukotriene Antagonists | ICI AMERICAS INC. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0337767-A1 | Cyclic amides | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |