Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 4/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5915126 | 0.80 | DRD2 (0.51) | HTR2CHTR2AHTR2BHTR1ADRD2 | |
| SCHEMBL9527372 | 0.76 | HTR2C (0.46) | HTR2CHTR2AHTR2BDRD2SLC6A2 | |
| SCHEMBL1074633 | 0.73 | HTR2C (0.47) | HTR2CHTR2AHTR2BHTR1ADRD2 | |
| SCHEMBL4125113 | 0.73 | HTR2C (0.39) | HTR2CHTR2AHTR2BHTR1AADRA1A | |
| SCHEMBL8055769 | 0.72 | HRH1 (0.56) | HTR2CHTR2AHTR2BHTR1AADRA1A | |
| SCHEMBL27526873 | 0.72 | CYP3A4 (0.39) | GSK3BCHRNA7SIGMAR1 | |
| SCHEMBL8422421 | 0.70 | HTR2C (0.43) | HTR2CHTR2AHTR2BSLC6A2SLC6A4 | |
| SCHEMBL8911446 | 0.69 | HTR2C (0.53) | HTR2CHTR2AHTR2BDRD2HTR3E | |
| SCHEMBL2429178 | 0.68 | HTR1A (0.51) | HTR1AADRA1ATSHRCYP2C19 | |
| SCHEMBL8422451 | 0.67 | HTR2B (0.44) | HTR2CHTR2AHTR2BHTR1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127357-A | N-((phenyl, benzodioxinyl or N-heteroarylpiperazinyl)alkyl)-N-(N-heteroaryl)substituted carboxamides | JOHN WYETH & BROTHER, LTD. (GB) | 2000-10-03 | — | — | US | disclosed |