Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | MMP8 | P22894 | 1/20 | 0.55 |
| ▸ | MMP14 | P50281 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 3/20 | 0.52 |
| ▸ | MPO | P05164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529083 | 0.82 | HTR2A (0.74) | MTNR1AMTNR1BHTR2ATSHRTRPM8 | |
| SCHEMBL1120761 | 0.81 | KDM4E (0.68) | MTNR1AMTNR1BHTR2ATSHRTRPM8 | |
| SCHEMBL10491369 | 0.80 | HTR2A (0.70) | HTR2ATSHRHTR1AMEN1KMT2A | |
| SCHEMBL9612263 | 0.80 | HTR2A (0.67) | MTNR1AMTNR1BHTR2ATSHRTRPM8 | |
| SCHEMBL15791145 | 0.79 | HTR2A (0.69) | MTNR1AMTNR1BHTR2ATSHRTRPM8 | |
| SCHEMBL446591 | 0.78 | CSNK2A1 (0.67) | MTNR1AMTNR1BHTR2ATRPM8MMP9 | |
| SCHEMBL25004737 | 0.78 | MTNR1A (0.64) | MTNR1AMTNR1BHTR2ATSHRTRPM8 | |
| SCHEMBL31292987 | 0.78 | MTNR1A (0.64) | MTNR1AMTNR1BHTR2ATSHRTRPM8 | |
| SCHEMBL11069253 | 0.77 | SNCA (0.71) | MTNR1AMTNR1BHTR2ATRPM8SLC6A4 | |
| SCHEMBL9527900 | 0.77 | HTR2A (0.58) | MTNR1AMTNR1BHTR2AHTR1AHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| US-4886802-A | ANALGESICS | ROUSSEL UCLAF (FR) | 1989-12-12 | — | — | US | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |