Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.67 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.67 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.66 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.66 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.65 |
| ▸ | MMP9 | P14780 | 1/20 | 0.63 |
| ▸ | MMP8 | P22894 | 1/20 | 0.63 |
| ▸ | MMP14 | P50281 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.58 |
| ▸ | SNCA | P37840 | 4/20 | 0.56 |
| ▸ | HTR1A | P08908 | 1/20 | 0.55 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.55 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.55 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.55 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15791145 | 0.86 | HTR2A (0.69) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| SCHEMBL1120761 | 0.86 | KDM4E (0.68) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| SCHEMBL10310234 | 0.83 | MTNR1A (0.68) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| SCHEMBL14297488 | 0.83 | HTR2C (0.73) | HTR2ATSHRSLC6A4HTR1AHTR1D | |
| SCHEMBL25004737 | 0.82 | MTNR1A (0.64) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| SCHEMBL31292987 | 0.82 | MTNR1A (0.64) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| Iodide SCHEMBL30672189 | 0.81 | MTNR1A (0.62) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| Iodide SCHEMBL26662755 | 0.81 | MTNR1A (0.62) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| Hydrochloric Acid SCHEMBL26662832 | 0.81 | MTNR1A (0.62) | HTR2ATRPM8MTNR1AMTNR1BGPR84 | |
| SCHEMBL30724496 | 0.80 | HTR2A (1.00) | HTR2ATRPM8GPR84TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160340354-A1 | METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS | PTC THERAPEUTICS, INC. | 2016-11-24 | — | — | US | disclosed |
| US-9351964-B2 | Methods for treating cancer and non-neoplastic conditions | PTC THERAPEUTICS, INC. (US) | 2016-05-31 | — | — | US | disclosed |
| US-20120202763-A1 | METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS | PTC THERAPEUTICS, INC (US) | 2012-08-09 | — | — | US | disclosed |
| US-20120136154-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | PTC THERAPEUTICS, INC. | 2012-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340354-A1 | METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS | HDGF, POLRMT, VEGFA | HTR2A 4569/4885TRPM8 4743/4885MTNR1A 2694/4885 |
| US-20120202763-A1 | METHODS FOR TREATING CANCER AND NON-NEOPLASTIC CONDITIONS | HDGF, POLRMT, VEGFA | HTR2A 4569/4885TRPM8 4743/4885MTNR1A 2694/4885 |
| US-20120136154-A1 | PROCESSES FOR THE PREPARATION OF SUBSTITUTED TETRAHYDRO BETA-CARBOLINES | TPH1, TPH2, HTR1B | HTR2A 49/4885TRPM8 4828/4885MTNR1A 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.