SCHEMBL9527900

SCHEMBL9527900

Cc1ccc2c(CCNCC#N)c[nH]c2c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 6/20 0.58
CHRNB2 P17787 1/20 0.48
CHRNA7 P36544 1/20 0.48
CHRNA4 P43681 1/20 0.48
MTNR1A P48039 1/20 0.47
MTNR1B P49286 1/20 0.47
MC5R P33032 1/20 0.44
MC3R P41968 1/20 0.44
MC1R Q01726 1/20 0.44
HTR1D P28221 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
ATM Q13315 1/20 0.44
PTGS1 P23219 1/20 0.44
PTGS2 P35354 1/20 0.44
PCSK9 Q8NBP7 1/20 0.43
MPO P05164 2/20 0.43
HTR1A P08908 2/20 0.42
HTR7 P34969 1/20 0.42
HTR6 P50406 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9531245 0.83 MTNR1A (0.62) HTR2AMTNR1AMTNR1BHTR6MAPT
SCHEMBL10491369 0.81 HTR2A (0.70) HTR2AMC5RMC3RMC1RHTR1A
SCHEMBL11992198 0.81 CHRNB2 (0.70) HTR2ACHRNB2CHRNA7CHRNA4MTNR1A
SCHEMBL15074715 0.79 HTR2A (0.59) HTR2ACHRNB2CHRNA7CHRNA4HTR1D
SCHEMBL1971950 0.78 HTR2A (0.56) HTR2ACHRNB2CHRNA7CHRNA4MTNR1A
Hydrochloric Acid SCHEMBL8951651 0.78 HTR2A (0.63) HTR2ACHRNB2CHRNA7CHRNA4MTNR1A
SCHEMBL9527677 0.77 MTNR1A (0.61) HTR2AMTNR1AMTNR1BMPOHTR1A
SCHEMBL8260107 0.76 HTR2A (0.73) HTR2ACHRNB2CHRNA7CHRNA4MTNR1A
SCHEMBL24460220 0.75 MTNR1A (0.80) HTR2AMTNR1AMTNR1BNPC1RAB9A
SCHEMBL26989142 0.75 MTNR1A (0.60) HTR2AMTNR1AMTNR1BHTR1DMPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0287468-B1 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM ROUSSEL-UCLAF (FR) 1993-03-10 EP disclosed
US-4886802-A ANALGESICS ROUSSEL UCLAF (FR) 1989-12-12 US disclosed