Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527227 | 0.87 | APP (0.44) | HTR6HTR1AHTR1DHTR1BKCNH2 | |
| Hydrochloric Acid SCHEMBL9526976 | 0.86 | APP (0.43) | HTR6HTR1AHTR1DHTR1BKCNH2 | |
| SCHEMBL9526689 | 0.76 | APP (0.42) | HTR6HTR1AKCNH2APPRORC | |
| SCHEMBL10123902 | 0.75 | HTR1B (0.63) | HTR6HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL1823282 | 0.75 | HTR1A (0.49) | HTR6HTR1AHTR1DHTR1BSLC6A4 | |
| Hydrochloric Acid SCHEMBL3262917 | 0.74 | HTR1A (0.48) | HTR6HTR1AHTR1DHTR1BSLC6A4 | |
| SCHEMBL8316249 | 0.72 | HTR6 (0.53) | HTR6SLC6A4HTR2C | |
| SCHEMBL10691162 | 0.71 | HTR6 (0.57) | HTR6HTR2C | |
| SCHEMBL9272212 | 0.71 | HTR1A (0.43) | HTR6HTR1AHTR1DHTR1BSLC6A4 | |
| Hydrochloric Acid SCHEMBL9274910 | 0.70 | HTR1A (0.42) | HTR6HTR1AHTR1DHTR1BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1022243-C | Indole derivatives and process for preparation thereof | GLAXO GROUP LTD (GB) | 1993-09-29 | — | — | CN | claimed |
| EP-0303507-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 1993-07-28 | — | — | EP | claimed |
| US-4997841-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | claimed |
| CN-1038807-A | The preparation method of indole derivatives | GLAXO GROUP LTD (GB) | 1990-01-17 | — | — | CN | claimed |
| EP-0303506-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | claimed |
| EP-0303507-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | claimed |
| CN-1022243-C | Indole derivatives and process for preparation thereof | GLAXO GROUP LTD (GB) | 1993-09-29 | — | — | CN | disclosed |
| EP-0303507-B1 | INDOLE DERIVATIVES | GLAXO GROUP LTD (GB) | 1993-07-28 | — | — | EP | disclosed |
| US-4997841-A | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-03-05 | — | — | US | disclosed |
| CN-1038807-A | The preparation method of indole derivatives | GLAXO GROUP LTD (GB) | 1990-01-17 | — | — | CN | disclosed |
| EP-0303507-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1989-02-15 | — | — | EP | disclosed |