Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | MPI | P34949 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.36 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8259928 | 0.94 | SIRT1 (0.49) | SIRT1HTTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL13585976 | 0.81 | AGTR1 (0.39) | SIRT1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL9528025 | 0.78 | XDH (0.33) | SIRT1HTTSMN1; SMN2KDM4EKCNH2 | |
| SCHEMBL8109107 | 0.73 | ADORA3 (0.41) | SIRT1HTTSMN1; SMN2KDM4ENPC1 | |
| SCHEMBL14394352 | 0.72 | AGTR1 (0.41) | SIRT1 | |
| SCHEMBL9529988 | 0.71 | NR1H3 (0.54) | NPC1RAB9AADORA3ADORA2AADORA1 | |
| SCHEMBL92739 | 0.70 | KCNH2 (0.46) | SMN1; SMN2THRBL3MBTL1KCNH2GPR84 | |
| SCHEMBL18529395 | 0.70 | KCNH2 (0.36) | KCNH2XDHCNR1CNR2 | |
| SCHEMBL13714538 | 0.69 | SIRT1 (0.36) | SIRT1XDHCNR1CNR2ALDH1A1 | |
| SCHEMBL7711334 | 0.68 | KCNH2 (0.50) | SMN1; SMN2KDM4ETHRBKCNH2GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527851-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| WO-1991017148-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-11-14 | — | — | WO | disclosed |