SCHEMBL9528388

SCHEMBL9528388

CS(=O)(=O)Nc1cc(NC=O)c([N+](=O)[O-])cc1Oc1ccccc1F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSPB1 P04792 2/20 0.46
MEN1 O00255 3/20 0.46
KMT2A Q03164 3/20 0.46
CYP19A1 P11511 6/20 0.45
MAPT P10636 2/20 0.45
ADORA3 P0DMS8 2/20 0.45
PTGS1 P23219 2/20 0.45
PTGS2 P35354 2/20 0.45
KDM4E B2RXH2 1/20 0.45
MLNR O43193 1/20 0.45
LMNA P02545 1/20 0.45
MMP1 P03956 1/20 0.45
MPO P05164 1/20 0.45
CYP1A2 P05177 1/20 0.45
GLA P06280 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2C9 P11712 1/20 0.45
HPGD P15428 1/20 0.45
TSHR P16473 1/20 0.45
TBXA2R P21731 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9550565 0.74 PTGS2 (0.48) HSPB1MEN1KMT2ACYP19A1MAPT
SCHEMBL9307858 0.73 HPGD (0.51) MEN1KMT2ACYP19A1MAPTADORA3
SCHEMBL10334608 0.73 PTGS1 (0.76) MEN1KMT2ACYP19A1MAPTADORA3
SCHEMBL6281034 0.71 CYP19A1 (0.65) MEN1KMT2ACYP19A1MAPTADORA3
SCHEMBL8942422 0.71 HPGD (0.45) MEN1KMT2ACYP19A1MAPTADORA3
SCHEMBL11181569 0.71 PTGS2 (0.57) MEN1KMT2ACYP19A1MAPTADORA3
SCHEMBL9574619 0.70 SMN1; SMN2 (0.60) MEN1KMT2ACYP19A1MAPTADORA3
SCHEMBL24193426 0.70 CYP19A1 (0.73) MEN1KMT2ACYP19A1MAPTADORA3
SCHEMBL9561587 0.69 SMN1; SMN2 (0.57) MEN1KMT2ACYP19A1MAPTADORA3
SCHEMBL20225775 0.68 GAA (0.47) MEN1KMT2ACYP19A1MAPTADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-5163236-A None JP disclosed
JP-H05163236-A 5-FORMAMINO-2-PHENOXYSULFONEANILIDE COMPOUND TAISHO PHARMACEUT CO LTD 1993-06-29 JP disclosed