Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ASAH1 | Q13510 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | ACER2 | Q5QJU3 | 1/20 | 0.36 |
| ▸ | CERT1 | Q9Y5P4 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 2/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529882 | 0.94 | METAP1 (0.40) | AKR1C3AKR1C2CYSLTR2CYSLTR1PPARG | |
| SCHEMBL9527532 | 0.93 | METAP1 (0.41) | KDM4EMEN1RECQLKMT2AAKR1C3 | |
| SCHEMBL9528238 | 0.92 | POLB (0.37) | ASAH1KDM4EMEN1RECQLKMT2A | |
| SCHEMBL9528551 | 0.88 | POLB (0.38) | ASAH1KDM4EALDH1A1POLBNPC1 | |
| SCHEMBL9527618 | 0.87 | PKM (0.38) | KDM4EKMT2AALDH1A1POLBNPC1 | |
| SCHEMBL9528360 | 0.86 | RAB9A (0.36) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL9528908 | 0.85 | NCEH1 (0.41) | KMT2AALDH1A1POLB | |
| SCHEMBL9527604 | 0.85 | FAAH (0.36) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL9528699 | 0.84 | HTT (0.39) | KDM4EMEN1KMT2AALDH1A1POLB | |
| SCHEMBL9530343 | 0.83 | POLB (0.36) | POLBNPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | claimed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | disclosed |