Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28808824 | 0.88 | RIPK1 (0.65) | RIPK1LMNAPPARGPPARABCAT2 | |
| SCHEMBL13744313 | 0.81 | RIPK1 (0.42) | RIPK1LMNAALDH1A1CYP3A4NPC1 | |
| SCHEMBL22624001 | 0.79 | RIPK1 (1.00) | RIPK1LMNA | |
| SCHEMBL22623858 | 0.79 | RIPK1 (1.00) | RIPK1LMNA | |
| SCHEMBL27945599 | 0.74 | RIPK1 (0.46) | RIPK1CNR1CNR2SMN1; SMN2 | |
| SCHEMBL27741015 | 0.74 | RIPK1 (0.60) | RIPK1CNR1CNR2BCAT2SMN1; SMN2 | |
| SCHEMBL27964869 | 0.74 | RIPK1 (0.46) | RIPK1LMNABCAT2NPC1RAB9A | |
| SCHEMBL873380 | 0.73 | ALDH1A1 (0.48) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8743244 | 0.73 | RIPK1 (0.49) | RIPK1LMNAMTNR1AMTNR1BALDH1A1 | |
| SCHEMBL8743250 | 0.73 | RIPK1 (0.49) | RIPK1LMNAMTNR1AMTNR1BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0531382-A1 | N-SUBSTITUTED-1,2,4-TRIAZOLONE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-03-17 | — | — | EP | disclosed |