Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529505 | 0.81 | LOXL2 (0.48) | LOXL2MAOBMAOASIRT1F2 | |
| SCHEMBL6993755 | 0.80 | LOXL2 (0.60) | LOXL2SMN1; SMN2 | |
| SCHEMBL6990842 | 0.80 | MAOB (0.57) | LOXL2MAOBMAOAF2 | |
| SCHEMBL9529857 | 0.78 | MEN1 (0.47) | MAOBMAOASMN1; SMN2RHEB | |
| SCHEMBL6826452 | 0.78 | LOXL2 (0.64) | LOXL2FFAR1SIRT1F2SMN1; SMN2 | |
| SCHEMBL6989797 | 0.78 | DRD2 (0.58) | LOXL2MAOBMAOADRD2DRD4 | |
| SCHEMBL6995621 | 0.77 | F2 (0.55) | LOXL2F2PCSK9RHEB | |
| SCHEMBL11403419 | 0.76 | LTA4H (0.47) | MAOBMAOAP2RX3 | |
| SCHEMBL9531674 | 0.75 | PDE10A (0.46) | MAOBMAOAFFAR1SMN1; SMN2 | |
| SCHEMBL9529663 | 0.73 | PDE10A (0.51) | FFAR1CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544821-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS. | PFIZER (US) | 1993-06-09 | — | — | EP | disclosed |
| WO-1992006088-A1 | INDOLE DERIVATIVES AS ANTIALLERGY AND ANTIINFLAMMATORY AGENTS | PFIZER INC. (US) | 1992-04-16 | — | — | WO | disclosed |