Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 5/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NAAA | Q02083 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530133 | 0.96 | CACNA2D1 (0.43) | TACR3CACNA2D1POLBALDH1A1MAPT | |
| Phosphoric Acid SCHEMBL9531932 | 0.94 | TACR3 (0.43) | TACR3CACNA2D1POLBP2RX3CYP1A2 | |
| SCHEMBL10369837 | 0.90 | GCGR (0.39) | TACR3CACNA2D1POLBCNR2 | |
| SCHEMBL10368160 | 0.84 | CACNA2D1 (0.41) | TACR3CACNA2D1POLBALDH1A1MAPT | |
| SCHEMBL9530046 | 0.83 | TACR3 (0.41) | TACR3CACNA2D1POLBALDH1A1MAPT | |
| SCHEMBL10367529 | 0.83 | TACR3 (0.39) | TACR3CACNA2D1POLBALDH1A1MAPT | |
| SCHEMBL10533270 | 0.83 | CACNA2D1 (0.44) | TACR3CACNA2D1POLBALDH1A1MAPT | |
| SCHEMBL9528534 | 0.81 | TACR3 (0.42) | TACR3CACNA2D1POLBCYP1A2CYP2D6 | |
| SCHEMBL9528223 | 0.80 | TACR3 (0.41) | TACR3CACNA2D1POLBCYP1A2CYP2D6 | |
| SCHEMBL9528466 | 0.80 | TACR3 (0.41) | TACR3ALDH1A1CYP1A2CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210044-B1 | HYDROXY AND ALKOXY PYRIMIDINES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | claimed |
| US-4711888-A | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-12-08 | — | — | US | claimed |
| EP-0210044-A2 | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0210044-B1 | HYDROXY AND ALKOXY PYRIMIDINES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | disclosed |
| US-4711888-A | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-12-08 | — | — | US | disclosed |
| EP-0210044-A2 | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-01-28 | — | — | EP | disclosed |