Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 7/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TACR2 | P21452 | 1/20 | 0.35 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
| ▸ | KCNH3 | Q9ULD8 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10367948 | 0.96 | CACNA2D1 (0.41) | CACNA2D1TACR3SLC2A1MAPTMEN1 | |
| Phosphoric Acid SCHEMBL10367954 | 0.89 | TACR3 (0.41) | CACNA2D1TACR3POLBALDH1A1TACR2 | |
| SCHEMBL9528534 | 0.84 | TACR3 (0.42) | CACNA2D1TACR3SMN1; SMN2POLBRAB9A | |
| SCHEMBL9529634 | 0.84 | TACR3 (0.42) | CACNA2D1TACR3SLC2A1MAPTSMN1; SMN2 | |
| SCHEMBL9528223 | 0.83 | TACR3 (0.41) | CACNA2D1TACR3SMN1; SMN2POLBRAB9A | |
| SCHEMBL10368262 | 0.83 | SLC2A1 (0.38) | CACNA2D1TACR3SLC2A1MAPTMEN1 | |
| SCHEMBL9527611 | 0.82 | TACR3 (0.41) | CACNA2D1TACR3KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9528466 | 0.82 | TACR3 (0.41) | TACR3MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9528353 | 0.82 | TACR3 (0.41) | CACNA2D1TACR3MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9527591 | 0.81 | FAAH (0.42) | TACR3GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0210044-B1 | HYDROXY AND ALKOXY PYRIMIDINES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | claimed |
| US-4711888-A | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-12-08 | — | — | US | claimed |
| EP-0210044-A2 | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0210044-B1 | HYDROXY AND ALKOXY PYRIMIDINES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4711888-A | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-12-08 | — | — | US | disclosed |
| EP-0210044-A2 | Hydroxy and alkoxy pyrimidines | PFIZER INC. (US) | 1987-01-28 | — | — | EP | disclosed |