Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529634 | 0.96 | TACR3 (0.42) | CACNA2D1TACR3POLBALDH1A1KDM4E | |
| Phosphoric Acid SCHEMBL9531932 | 0.90 | TACR3 (0.43) | CACNA2D1TACR3POLBP2RX3SMN1; SMN2 | |
| SCHEMBL10369837 | 0.86 | GCGR (0.39) | CACNA2D1TACR3POLB | |
| SCHEMBL10367948 | 0.83 | CACNA2D1 (0.41) | CACNA2D1TACR3POLBALDH1A1KDM4E | |
| Phosphoric Acid SCHEMBL10367954 | 0.80 | TACR3 (0.41) | CACNA2D1TACR3POLBALDH1A1TLR7 | |
| SCHEMBL10368160 | 0.80 | CACNA2D1 (0.41) | CACNA2D1TACR3POLBALDH1A1MAPT | |
| SCHEMBL9529639 | 0.80 | ALDH1A1 (0.39) | TACR3POLBALDH1A1KDM4EMAPT | |
| SCHEMBL9530046 | 0.79 | TACR3 (0.41) | CACNA2D1TACR3POLBALDH1A1MAPT | |
| SCHEMBL10367529 | 0.79 | TACR3 (0.39) | CACNA2D1TACR3POLBALDH1A1MAPT | |
| SCHEMBL9527790 | 0.79 | TACR3 (0.41) | CACNA2D1TACR3POLBALDH1A1GPR88 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| EP-0210044-B1 | HYDROXY AND ALKOXY PYRIMIDINES | PFIZER INC. (US) | 1990-08-29 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |