Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | NCEH1 | Q6PIU2 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9528908 | 0.94 | NCEH1 (0.41) | CHRNB2CHRNB4CHRNA3CHRNA4NCEH1 | |
| SCHEMBL9527810 | 0.87 | PKM (0.39) | ALDH1A1PKMKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL9528133 | 0.86 | NCEH1 (0.37) | CHRNB2CHRNB4CHRNA3CHRNA4NCEH1 | |
| SCHEMBL9527715 | 0.85 | MAPT (0.35) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9530047 | 0.82 | MAPT (0.34) | ALDH1A1PKMKMT2ARAB9ASMN1; SMN2 | |
| SCHEMBL9528551 | 0.81 | POLB (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL10367949 | 0.81 | METAP1 (0.35) | ALDH1A1KMT2ATSHR | |
| SCHEMBL9528238 | 0.80 | POLB (0.37) | ALDH1A1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9527618 | 0.80 | PKM (0.38) | ALDH1A1PKMKMT2ANPC1RAB9A | |
| Phosphoric Acid SCHEMBL10367955 | 0.80 | GAA (0.36) | KMT2ARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | claimed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| EP-0319170-A2 | Acyl derivatives of hydroxy pyrimidines | PFIZER INC. (US) | 1989-06-07 | — | — | EP | disclosed |