Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GPR88 | Q9GZN0 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530343 | 0.94 | POLB (0.36) | MAPTNPSR1CACNA1FCACNA1DCACNA1S | |
| SCHEMBL9528360 | 0.85 | RAB9A (0.36) | NPSR1RAB9AALOX5ALDH1A1TSHR | |
| SCHEMBL9527810 | 0.84 | PKM (0.39) | MAPTNPSR1RAB9AALDH1A1TSHR | |
| SCHEMBL9529753 | 0.82 | CHRNB2 (0.39) | RAB9AALDH1A1TSHRKMT2APKM | |
| SCHEMBL9527715 | 0.82 | MAPT (0.35) | MAPTNPSR1RAB9AL3MBTL1ALDH1A1 | |
| SCHEMBL9527604 | 0.80 | FAAH (0.36) | MAPTRAB9AALDH1A1GPR88MEN1 | |
| SCHEMBL9528447 | 0.80 | TACR3 (0.38) | ALDH1A1GPR88KLK7 | |
| SCHEMBL9529632 | 0.80 | TACR3 (0.39) | RAB9AGPR88SMN1; SMN2 | |
| SCHEMBL9528551 | 0.79 | POLB (0.38) | NPSR1RAB9AALDH1A1SMN1; SMN2KLK7 | |
| SCHEMBL10367949 | 0.79 | METAP1 (0.35) | MAPTL3MBTL1ALDH1A1TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |