Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216124 | 0.76 | AKR1B1 (0.66) | MAPTMEN1KMT2ANPSR1 | |
| SCHEMBL13721336 | 0.69 | KDM4E (0.49) | SMN1; SMN2POLBLMNAKDM4EMEN1 | |
| SCHEMBL9374161 | 0.69 | ALOX15 (0.43) | SMN1; SMN2LMNAALOX15KDM4EMAPT | |
| SCHEMBL9529811 | 0.68 | RECQL (0.62) | SMN1; SMN2POLBLMNAALOX15MAPT | |
| SCHEMBL13721278 | 0.67 | POLB (1.00) | SMN1; SMN2POLBLMNAKDM4EHTT | |
| SCHEMBL5014224 | 0.66 | RECQL (0.83) | SMN1; SMN2LMNAALOX15MAPT | |
| SCHEMBL13720606 | 0.66 | LMNA (0.74) | SMN1; SMN2LMNAKDM4EMAPTCYP2D6 | |
| SCHEMBL23914949 | 0.65 | MAPT (0.67) | POLBALOX15MAPTKMT2A | |
| SCHEMBL6885992 | 0.65 | LMNA (0.77) | SMN1; SMN2POLBLMNAALOX15HTT | |
| SCHEMBL24093933 | 0.64 | HSD17B10 (0.58) | SMN1; SMN2LMNAALOX15KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295051-B1 | PREPARATION OF OXOPHTHALAZINYL ACETIC ACIDS HAVING BENZOTHIAZOLE OR OTHER HETEROCYCLIC SIDE CHAINS | PFIZER INC. (US) | 1993-06-09 | — | — | EP | disclosed |
| US-4900844-A | Intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4868301-A | Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1989-09-19 | — | — | US | disclosed |