Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 12/20 | 0.33 |
| ▸ | DRD2 | P14416 | 4/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7902262 | 0.82 | HTR1A (0.39) | HTR1ADRD2 | |
| SCHEMBL7484841 | 0.80 | MAPT (0.38) | SIGMAR1 | |
| SCHEMBL9701097 | 0.69 | SIGMAR1 (0.34) | OPRM1SIGMAR1ADRA1A | |
| SCHEMBL7797306 | 0.68 | MEN1 (0.36) | — | |
| SCHEMBL9702700 | 0.68 | SIGMAR1 (0.33) | SIGMAR1 | |
| SCHEMBL8844255 | 0.66 | ADRA2A (0.30) | — | |
| SCHEMBL7903496 | 0.66 | SIGMAR1 (0.32) | OPRD1OPRM1SIGMAR1 | |
| SCHEMBL9702149 | 0.66 | ALDH1A1 (0.33) | — | |
| SCHEMBL9701174 | 0.65 | SLC6A2 (0.36) | — | |
| SCHEMBL7896255 | 0.65 | SIGMAR1 (0.36) | OPRD1OPRM1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384522-B1 | Antiviral tetrahydroimidazo[1,4]benzodiazepin-2-thiones | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-01-13 | — | — | EP | disclosed |