Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 4/20 | 0.61 |
| ▸ | CTSL | P07711 | 4/20 | 0.61 |
| ▸ | MAOA | P21397 | 4/20 | 0.58 |
| ▸ | DHODH | Q02127 | 2/20 | 0.52 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.51 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.51 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.51 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.51 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 4/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MDH2 | P40926 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529969 | 0.81 | CYP3A4 (0.57) | CTSVCTSLMAOADHODHMAOB | |
| SCHEMBL2795363 | 0.80 | CTSV (0.65) | CTSVCTSLMAOAMAOBACHE | |
| SCHEMBL9529962 | 0.79 | CYP3A4 (0.54) | CTSVCTSLMAOADHODHGABRA1 | |
| SCHEMBL14853963 | 0.78 | KDM4E (0.59) | MAOAACHEALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL22725987 | 0.77 | IP6K1 (0.60) | CTSVCTSLMAOAMAOBACHE | |
| SCHEMBL7255064 | 0.77 | MAOA (0.64) | CTSVCTSLMAOAGABRA1GABRG2 | |
| SCHEMBL31498142 | 0.77 | MAOA (0.61) | CTSVCTSLMAOAGABRA1GABRG2 | |
| SCHEMBL7256169 | 0.75 | CTSV (0.66) | CTSVCTSLMAOAGABRA1GABRG2 | |
| SCHEMBL7253632 | 0.75 | CTSV (0.66) | CTSVCTSLMAOAGABRA1GABRG2 | |
| SCHEMBL14422827 | 0.75 | CTSV (0.83) | CTSVCTSLMAOAGABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7205309-B2 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. (US) | 2007-04-17 | — | — | US | disclosed |
| EP-1560816-A1 | QUINAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-10 | — | — | EP | disclosed |
| US-20040029901-A1 | Quinazoline derivatives | HOFFMANN-LA ROCHE INC. | 2004-02-12 | — | — | US | disclosed |
| WO-2004005265-A1 | QUINAZOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040029901-A1 | Quinazoline derivatives | GPR119, NQO2, CYP7A1 | CTSV 2946/4885CTSL 2882/4885MAOA 1346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.